InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ap2b1

Summary

InnateDB Gene

IDBG-205183.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ap2b1

Gene Name

adaptor-related protein complex 2, beta 1 subunit

Synonyms

1300012O03Rik; AI788979

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035152

Encoded Proteins

IDBP-205187

adaptor-related protein complex 2, beta 1 subunit

IDBP-205189

adaptor-related protein complex 2, beta 1 subunit

IDBP-539697

adaptor-related protein complex 2, beta 1 subunit

IDBP-717906

IDBP-718059

IDBP-716768

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006125:
The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:83299024-83405035

Strand

Forward strand

Band

Transcripts

ENSMUST00000018875	ENSMUSP00000018875
ENSMUST00000065692	ENSMUSP00000070714
ENSMUST00000132178
ENSMUST00000142680	ENSMUSP00000116562
ENSMUST00000176523	ENSMUSP00000135445
ENSMUST00000176944	ENSMUSP00000134798
ENSMUST00000176430	ENSMUSP00000134779

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0030276	clathrin binding
GO:0032403	protein complex binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0048268	clathrin coat assembly

Cellular Component

GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0030117	membrane coat
GO:0030118	clathrin coat
GO:0030131	clathrin adaptor complex

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000006125

View Gene Order

Pathways

NETPATH

REACTOME

REACT_222404

WNT5A-dependent internalization of FZD4 pathway

REACT_203917

EGFR downregulation pathway

REACT_189085

Disease pathway

REACT_214014

Signaling by Wnt pathway

REACT_257923

Recycling pathway of L1 pathway

REACT_203664

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_226355

beta-catenin independent WNT signaling pathway

REACT_232605

Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway

REACT_230745

Immune System pathway

REACT_202778

Retrograde neurotrophin signalling pathway

REACT_214043

PCP/CE pathway pathway

REACT_196550

MHC class II antigen presentation pathway

REACT_242976

Signaling by EGFR pathway

REACT_261444

Axon guidance pathway

REACT_219680

L1CAM interactions pathway

REACT_248921

Signalling by NGF pathway

REACT_229531

Adaptive Immune System pathway

REACT_259290

Neuronal System pathway

REACT_188576

Developmental Biology pathway

REACT_253367

Trafficking of GluR2-containing AMPA receptors pathway

REACT_237883

NGF signalling via TRKA from the plasma membrane pathway

REACT_188257

Signal Transduction pathway

REACT_244428

Trafficking of AMPA receptors pathway

REACT_233318

Transmission across Chemical Synapses pathway

REACT_188180

Signaling by EGFR in Cancer pathway

KEGG

mmu05016

Huntington's disease pathway

mmu04144

Endocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

NetPath_7

TGF_beta_Receptor pathway

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_12435

Retrograde neurotrophin signalling pathway

REACT_12484

EGFR downregulation pathway

REACT_9417

Signaling by EGFR pathway

REACT_11200

Nef Mediated CD8 Down-regulation pathway

REACT_11166

Nef Mediated CD4 Down-regulation pathway

REACT_22365

Recycling pathway of L1 pathway

REACT_22205

L1CAM interactions pathway

REACT_172581

PCP/CE pathway pathway

REACT_111045

Developmental Biology pathway

REACT_11061

Signalling by NGF pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_172599

WNT5A-dependent internalization of FZD4 pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_11045

Signaling by Wnt pathway

REACT_18266

Axon guidance pathway

REACT_111102

Signal Transduction pathway

REACT_11149

Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_228189

EPH-ephrin mediated repulsion of cells pathway

REACT_6185

HIV Infection pathway

REACT_228170

EPH-Ephrin signaling pathway

REACT_6835

The role of Nef in HIV-1 replication and disease pathogenesis pathway

REACT_6288

Host Interactions of HIV factors pathway

REACT_116125

Disease pathway

KEGG

hsa04144

Endocytosis pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

Q9DBG3

TrEMBL

H3BJ06 Q5SWR0 Q5SWR1

UniProt Splice Variant

Entrez Gene

71770

UniGene

Mm.39053

RefSeq

NM_001035854 XM_006534258 NM_027915

OMIM

CCDS

CCDS25161 CCDS25162

HPRD

IMGT

MGI ID

MGI:1919020

MGI Symbol

Ap2b1

EMBL

AK004975 AK138434 AL603711 BC046772

GenPept

AAH46772 BAB23711 BAE23661

RNA Seq Atlas

71770