Version 5.4
Mus musculus Gene: Apcs
Summary
InnateDB Gene IDBG-205704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apcs
Gene Name serum amyloid P-component
Synonyms Sap
Species Mus musculus
Ensembl Gene ENSMUSG00000026542
Encoded Proteins
IDBP-205706
serum amyloid P-component
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21278351
Apcs is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccination in humans. Murine Apcs exhibited a similar, albeit very weak, activity.
InnateDB Annotation from Orthologs
Summary
PMID 21278351
[Homo sapiens] APCS is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccination in humans. APCS-DNA complex showed significant defects in innate immune activation, and specifically inhibits the functions of HMGB1 and antimicrobial peptide LL37.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132703:
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:172893962-172895054
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000027824 ENSMUSP00000027824
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001849 complement component C1q binding
GO:0005509 calcium ion binding
GO:0046790 virion binding
GO:0046872 metal ion binding
Biological Process
GO:0006461 protein complex assembly
GO:0045087 innate immune response (InnateDB)
GO:0045656 negative regulation of monocyte differentiation
GO:0046597 negative regulation of viral entry into host cell
GO:0048525 negative regulation of viral process
GO:1903016 negative regulation of exo-alpha-sialidase activity
GO:1903019 negative regulation of glycoprotein metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0031012 extracellular matrix
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132703
View Gene Order
ENSBTAG00000019616
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_198563
Amyloids pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75925
Amyloids pathway
REACT_116125
Disease pathway
REACT_206540
Amyloids pathway
REACT_207087
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P12246
TrEMBL Q4JFI8
UniProt Splice Variant
Entrez Gene 20219
UniGene Mm.330510
RefSeq NM_011318
OMIM
CCDS CCDS15520
HPRD
IMGT
MGI ID MGI:98229
MGI Symbol Apcs
EMBL AK144248 AK165699 BC061125 CH466520 HQ283363 M23248 M23552 M29535 S40320 X14079 X16899 Y00426
GenPept AAA40091 AAA40092 AAA40093 AAH61125 AAY88178 ADZ99751 BAE25796 BAE38344 CAA32243 CAA34774 CAA68488 EDL39002
RNA Seq Atlas 20219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca