InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: APCS

Summary

InnateDB Gene

IDBG-630753.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APCS

Gene Name

Serum amyloid P-component

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019616

Encoded Proteins

IDBP-682232

Serum amyloid P-component

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21278351

[Homo sapiens] APCS is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccination in humans. APCS-DNA complex showed significant defects in innate immune activation, and specifically inhibits the functions of HMGB1 and antimicrobial peptide LL37.

PMID 21278351

[Mus musculus] Apcs is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccination in humans. Murine Apcs exhibited a similar, albeit very weak, activity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132703:
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:10245766-10246803

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026133

ENSBTAP00000026133

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001849	complement component C1q binding
GO:0005509	calcium ion binding
GO:0046790	virion binding
GO:0046872	metal ion binding

Biological Process

GO:0045087	innate immune response
GO:0045656	negative regulation of monocyte differentiation
GO:0046597	negative regulation of viral entry into host cell
GO:0048525	negative regulation of viral process
GO:1903016	negative regulation of exo-alpha-sialidase activity
GO:1903019	negative regulation of glycoprotein metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000132703

View Gene Order

ENSMUSG00000026542

View Gene Order

Pathways

NETPATH

REACTOME

REACT_206540

Amyloids pathway

REACT_207087

Disease pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

Amyloids pathway

Disease pathway

Disease pathway

Amyloids pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q3T004

TrEMBL

UniProt Splice Variant

Entrez Gene

514488

UniGene

Bt.17678

RefSeq

NM_001034466

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102623

GenPept

AAI02624

RNA Seq Atlas

514488