InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vamp3

Summary

InnateDB Gene

IDBG-206034.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vamp3

Gene Name

vesicle-associated membrane protein 3

Synonyms

ceb; D130027G05Rik; VAMP-3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028955

Encoded Proteins

IDBP-206036

vesicle-associated membrane protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049245:
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:151047300-151057963

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030797	ENSMUSP00000030797
ENSMUST00000155446
ENSMUST00000125205

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005484	SNAP receptor activity
GO:0005515	protein binding
GO:0017075	syntaxin-1 binding

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0006461	protein complex assembly
GO:0006906	vesicle fusion
GO:0007269	neurotransmitter secretion
GO:0016192	vesicle-mediated transport
GO:0017156	calcium ion-dependent exocytosis
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035493	SNARE complex assembly
GO:0042147	retrograde transport, endosome to Golgi
GO:0043001	Golgi to plasma membrane protein transport

Cellular Component

GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030054	cell junction
GO:0030136	clathrin-coated vesicle
GO:0030141	secretory granule
GO:0030665	clathrin-coated vesicle membrane
GO:0031201	SNARE complex
GO:0031410	cytoplasmic vesicle
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0043231	intracellular membrane-bounded organelle
GO:0055037	recycling endosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000049245

View Gene Order

ENSBTAG00000014726

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04130

SNARE interactions in vesicular transport pathway

mmu04145

Phagosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04130

SNARE interactions in vesicular transport pathway

hsa04145

Phagosome pathway

INOH

PID NCI

arf6_traffickingpathway

Arf6 trafficking events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.397096 Mm.403031 Mm.406854 Mm.407170

RefSeq

NM_009498

OMIM

CCDS

CCDS18979

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas