InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VAMP3

Summary

InnateDB Gene

IDBG-88198.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAMP3

Gene Name

vesicle-associated membrane protein 3

Synonyms

CEB

Species

Homo sapiens

Ensembl Gene

ENSG00000049245

Encoded Proteins

IDBP-88200

vesicle-associated membrane protein 3 (cellubrevin)

IDBP-722409

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:7771269-7781432

Strand

Forward strand

Band

p36.23

Transcripts

ENST00000054666	ENSP00000054666
ENST00000470357	ENSP00000465820
ENST00000487194

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0017075	syntaxin-1 binding

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0006461	protein complex assembly
GO:0006887	exocytosis
GO:0006904	vesicle docking involved in exocytosis
GO:0016192	vesicle-mediated transport
GO:0017156	calcium ion-dependent exocytosis
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035493	SNARE complex assembly
GO:0042147	retrograde transport, endosome to Golgi
GO:0043001	Golgi to plasma membrane protein transport
GO:0061025	membrane fusion

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030054	cell junction
GO:0030136	clathrin-coated vesicle
GO:0030141	secretory granule
GO:0030665	clathrin-coated vesicle membrane
GO:0031201	SNARE complex
GO:0031410	cytoplasmic vesicle
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0043231	intracellular membrane-bounded organelle
GO:0045202	synapse
GO:0055037	recycling endosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028955

View Gene Order

ENSBTAG00000014726

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04130

SNARE interactions in vesicular transport pathway

hsa04145

Phagosome pathway

INOH

PID NCI

arf6_traffickingpathway

Arf6 trafficking events

Cross-References

SwissProt

TrEMBL

K7EKX0

UniProt Splice Variant

Entrez Gene

9341

UniGene

Hs.610319 Hs.66708 Hs.706279

RefSeq

NM_004781

HUGO

HGNC:12644

OMIM

603657

CCDS

CCDS88

HPRD

04711

IMGT

EMBL

Z98884

GenPept

RNA Seq Atlas

9341