Homo sapiens Gene: VAMP3

Summary
InnateDB Gene IDBG-88198.6
Last Modified 2013-04-25   [Report errors or provide feedback]
Gene Symbol VAMP3
Gene Name vesicle-associated membrane protein 3
Synonyms CEB
Species Homo sapiens
Ensembl Gene ENSG00000049245
Encoded Proteins
IDBP-88200 vesicle-associated membrane protein 3 (cellubrevin)
IDBP-722409
Entrez Gene
Summary Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1: 7831329-7841492
Strand Forward strand
Band p36.23
Transcripts
ENST00000054666  ENSP00000054666
ENST00000470357  ENSP00000465820
ENST00000487194 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein‑Protein  26
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 1 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0000149 SNARE binding
GO:0005515 protein binding
GO:0017075 syntaxin-1 binding
Biological Process
GO:0001921 positive regulation of receptor recycling
GO:0006461 protein complex assembly
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0006944 cellular membrane fusion
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0017156 calcium ion-dependent exocytosis
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042147 retrograde transport, endosome to Golgi
GO:0043001 Golgi to plasma membrane protein transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral to membrane
GO:0016324 apical plasma membrane
GO:0030054 cell junction
GO:0030136 clathrin-coated vesicle
GO:0030141 secretory granule
GO:0030665 clathrin-coated vesicle membrane
GO:0031201 SNARE complex
GO:0031410 cytoplasmic vesicle
GO:0043005 neuron projection
GO:0043229 intracellular organelle
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
GO:0055037 recycling endosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000028955 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000014726 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
hsa04145  Phagosome
hsa04130  SNARE interactions in vesicular transport
INOH
PID BIOCARTA
PID NCI
arf6_traffickingpathway Arf6 trafficking events
Cross-References
SwissProt Q15836 
TrEMBL Q6FGG2
UniProt Splice Variant
Entrez Gene 9341 
UniGene Hs.610319 Hs.66708 Hs.706279
RefSeq NM_004781 
HUGO 12644 
OMIM 603657
CCDS CCDS88 
HPRD 04711
IMGT
EMBL AK316558 BC003570 BC007050 BT007327 CH471130 CR542145 CR542154 U64520 Z98884
GenPept AAB05814  AAH03570  AAH07050  AAP35991  BAG38147  CAB63146  CAG46942  CAG46951  EAW71582 
ImmGen VAMP3 (murine) 
RNA Seq Atlas 9341