Version 5.4
| Mus musculus Gene: Tnfrsf25 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Gene | IDBG-206339.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tnfrsf25 | ||||||||
| Gene Name | tumor necrosis factor receptor superfamily, member 25 | ||||||||
| Synonyms | APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3; TRAMP; Wsl; WSL-1; WSL-LR | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000024793 | ||||||||
| Encoded Proteins |
tumor necrosis factor receptor superfamily, member 25
tumor necrosis factor receptor superfamily, member 25
|
||||||||
| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000215788:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008] |
||||||||
| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 4:152115934-152120119 | ||||||||
| Strand | Forward strand | ||||||||
| Band | E2 | ||||||||
| Transcripts |
|
||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Orthologs | |||||||||
|
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||
| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Cytokine-cytokine receptor interaction pathway
|
||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
TWEAK pathway
|
||||||||
| REACTOME | |||||||||
| KEGG |
Cytokine-cytokine receptor interaction pathway
|
||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | B1AWN9 Q8VD70 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 85030 | ||||||||
| UniGene | Mm.101198 | ||||||||
| RefSeq | NM_001291010 NM_033042 XM_006539318 XM_006539320 XM_006539321 XM_006539322 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS38983 CCDS71527 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1934667 | ||||||||
| MGI Symbol | Tnfrsf25 | ||||||||
| EMBL | AL772240 BC017526 CH466594 | ||||||||
| GenPept | AAH17526 EDL14924 EDL14925 | ||||||||
| RNA Seq Atlas | 85030 | ||||||||