Version 5.4
Bos taurus Gene: BT.30010
Summary
InnateDB Gene IDBG-633838.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.30010
Gene Name tumor necrosis factor receptor superfamily member 25 precursor
Synonyms TNFRSF12
Species Bos taurus
Ensembl Gene ENSBTAG00000006519
Encoded Proteins
IDBP-685581
tumor necrosis factor receptor superfamily member 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000215788:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:47751957-47756269
Strand Forward strand
Band
Transcripts
ENSBTAT00000008557 ENSBTAP00000008557
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000024793
View Gene Order
ENSG00000215788
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_26
TWEAK pathway
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BHL8
UniProt Splice Variant
Entrez Gene 783432
UniGene Bt.30010
RefSeq NM_001144077 XM_005217148 XM_005217149 XM_005217150 XM_005217151
HUGO HGNC:11910
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02043084
GenPept
RNA Seq Atlas 783432

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca