Mus musculus Gene: Siglec1 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-206881.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | Siglec1 | ||||||||||||||||||
Gene Name | sialic acid binding Ig-like lectin 1, sialoadhesin | ||||||||||||||||||
Synonyms | Cd169; Siglec-1; Sn | ||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||
Ensembl Gene | ENSMUSG00000027322 | ||||||||||||||||||
Encoded Proteins |
sialic acid binding Ig-like lectin 1, sialoadhesin
sialic acid binding Ig-like lectin 1, sialoadhesin
sialic acid binding Ig-like lectin 1, sialoadhesin
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||
Summary |
Siglec1 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
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InnateDB Annotation from Orthologs | |||||||||||||||||||
Summary |
[Homo sapiens] SIGLEC1 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
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Entrez Gene | |||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088827:
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 2:131069220-131086765 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | F1 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME | |||||||||||||||||||
KEGG |
Cell adhesion molecules (CAMs) pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME | |||||||||||||||||||
KEGG |
Cell adhesion molecules (CAMs) pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q62230 | ||||||||||||||||||
TrEMBL | G3X8X6 Q6KAT6 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 20612 | ||||||||||||||||||
UniGene | Mm.1374 | ||||||||||||||||||
RefSeq | NM_011426 XM_006499049 XM_006499050 XM_006499051 | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS16754 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
MGI ID | MGI:99668 | ||||||||||||||||||
MGI Symbol | Siglec1 | ||||||||||||||||||
EMBL | AK131121 AL831736 AL833771 CH466519 U92833 U92834 U92836 U92837 U92838 U92839 U92840 U92841 U92842 Z36233 Z36234 Z36293 | ||||||||||||||||||
GenPept | AAB95641 BAD21371 CAA85268 CAA85269 CAA85290 EDL28300 | ||||||||||||||||||
RNA Seq Atlas | 20612 | ||||||||||||||||||