Mus musculus Gene: Siglec1
Summary
InnateDB Gene IDBG-206881.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Siglec1
Gene Name sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms Cd169; Siglec-1; Sn
Species Mus musculus
Ensembl Gene ENSMUSG00000027322
Encoded Proteins
sialic acid binding Ig-like lectin 1, sialoadhesin
sialic acid binding Ig-like lectin 1, sialoadhesin
sialic acid binding Ig-like lectin 1, sialoadhesin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Siglec1 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] SIGLEC1 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088827:
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:131069220-131086765
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000028794 ENSMUSP00000028794
ENSMUST00000110227 ENSMUSP00000105856
ENSMUST00000110226 ENSMUSP00000105855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0007155 cell adhesion
GO:0045087 innate immune response (InnateDB)
GO:0070234 positive regulation of T cell apoptotic process
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt Q62230
TrEMBL G3X8X6 Q6KAT6
UniProt Splice Variant
Entrez Gene 20612
UniGene Mm.1374
RefSeq NM_011426 XM_006499049 XM_006499050 XM_006499051
OMIM
CCDS CCDS16754
HPRD
IMGT
MGI ID MGI:99668
MGI Symbol Siglec1
EMBL AK131121 AL831736 AL833771 CH466519 U92833 U92834 U92836 U92837 U92838 U92839 U92840 U92841 U92842 Z36233 Z36234 Z36293
GenPept AAB95641 BAD21371 CAA85268 CAA85269 CAA85290 EDL28300
RNA Seq Atlas 20612