Version 5.4
Mus musculus Gene: Arhgef16
Summary
InnateDB Gene IDBG-207040.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef16
Gene Name Rho guanine nucleotide exchange factor (GEF) 16
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000029032
Encoded Proteins
IDBP-207042
Rho guanine nucleotide exchange factor (GEF) 16
IDBP-534542
Rho guanine nucleotide exchange factor (GEF) 16
IDBP-532133
Rho guanine nucleotide exchange factor (GEF) 16
IDBP-625423
Rho guanine nucleotide exchange factor (GEF) 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130762:
Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:154278486-154301676
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000030898 ENSMUSP00000030898
ENSMUST00000144145
ENSMUST00000143141
ENSMUST00000129189
ENSMUST00000154895 ENSMUSP00000121273
ENSMUST00000152947 ENSMUSP00000119398
ENSMUST00000169623 ENSMUSP00000126296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017048 Rho GTPase binding
GO:0030165 PDZ domain binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0032863 activation of Rac GTPase activity
GO:0032864 activation of Cdc42 GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0060326 cell chemotaxis
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130762
View Gene Order
ENSBTAG00000020837
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_210090
Rho GTPase cycle pathway
REACT_248921
Signalling by NGF pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.38481
RefSeq NM_001112744 XM_006538828 XM_006538829
OMIM
CCDS CCDS51399
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca