InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PIK3C2A

Summary

InnateDB Gene

IDBG-632709.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3C2A

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004901

Encoded Proteins

IDBP-684348

phosphoinositide-3-kinase, class 2, alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011405:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:35867460-35912334

Strand

Forward strand

Band

Transcripts

ENSBTAT00000046627

ENSBTAP00000043907

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity

Biological Process

GO:0006897	endocytosis
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005942	phosphatidylinositol 3-kinase complex
GO:0016020	membrane
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome