Version 5.4
Bos taurus Gene: PTPN14
Summary
InnateDB Gene IDBG-637822.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN14
Gene Name tyrosine-protein phosphatase non-receptor type 14
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021553
Encoded Proteins
IDBP-689857
protein tyrosine phosphatase, non-receptor type 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152104:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:70619178-70749808
Strand Forward strand
Band
Transcripts
ENSBTAT00000028717 ENSBTAP00000028717
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0001946 lymphangiogenesis
GO:0006470 protein dephosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0016311 dephosphorylation
GO:0046825 regulation of protein export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000152104
View Gene Order
ENSMUSG00000026604
View Gene Order
Cross-References
SwissProt
TrEMBL E1BEZ8
UniProt Splice Variant
Entrez Gene 518798
UniGene Bt.43316
RefSeq NM_001192499 XM_005217361 XM_005217362
HUGO HGNC:9647
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02043681 DAAA02043682 DAAA02043683
GenPept
RNA Seq Atlas 518798

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca