InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nek2

Summary

InnateDB Gene

IDBG-208875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nek2

Gene Name

NIMA (never in mitosis gene a)-related expressed kinase 2

Synonyms

AA617254; C77054

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026622

Encoded Proteins

IDBP-208877

NIMA (never in mitosis gene a)-related expressed kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117650:
This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:191821444-191833050

Strand

Forward strand

Band

Transcripts

ENSMUST00000027931	ENSMUSP00000027931
ENSMUST00000126446
ENSMUST00000150839
ENSMUST00000136733

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding
GO:0046872	metal ion binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0001824	blastocyst development
GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0007126	meiotic nuclear division
GO:0043392	negative regulation of DNA binding
GO:0046777	protein autophosphorylation
GO:0051299	centrosome separation
GO:0051988	regulation of attachment of spindle microtubules to kinetochore
GO:0090307	spindle assembly involved in mitosis
GO:1903126	negative regulation of centriole-centriole cohesion

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000794	condensed nuclear chromosome
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005874	microtubule
GO:0030496	midbody
GO:0043234	protein complex
GO:0045171	intercellular bridge