InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Igf2bp1

Summary

InnateDB Gene

IDBG-209747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Igf2bp1

Gene Name

insulin-like growth factor 2 mRNA binding protein 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000013415

Encoded Proteins

IDBP-209749

insulin-like growth factor 2 mRNA binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159217:
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:95957163-96005940

Strand

Reverse strand

Band

Transcripts

ENSMUST00000013559	ENSMUSP00000013559
ENSMUST00000138513
ENSMUST00000152896
ENSMUST00000146586
ENSMUST00000141515

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0045182	translation regulator activity
GO:0048027	mRNA 5'-UTR binding

Biological Process

GO:0006403	RNA localization
GO:0010610	regulation of mRNA stability involved in response to stress
GO:0017148	negative regulation of translation
GO:0051028	mRNA transport
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0010494	cytoplasmic stress granule
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0030529	ribonucleoprotein complex
GO:0043197	dendritic spine
GO:0048471	perinuclear region of cytoplasm
GO:0070937	CRD-mediated mRNA stability complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000159217

View Gene Order

ENSBTAG00000011736

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22166

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

Cross-References

SwissProt

O88477

TrEMBL

UniProt Splice Variant

Entrez Gene

140486

UniGene

Mm.294769 Mm.490105

RefSeq

NM_009951

OMIM

CCDS

CCDS25286

HPRD

IMGT

MGI ID

MGI:1890357

MGI Symbol

Igf2bp1

EMBL

AF061569 AK013940 AK044850 AL603682 AL606704 BC051679

GenPept

AAC72743 AAH51679 BAB29071 BAC32119 CAM18266 CAM22496

RNA Seq Atlas

140486