Version 5.4
Bos taurus Gene: IGF2BP1
Summary
InnateDB Gene IDBG-638842.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGF2BP1
Gene Name insulin-like growth factor 2 mRNA-binding protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011736
Encoded Proteins
IDBP-690950
insulin-like growth factor 2 mRNA binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159217:
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38137127-38178538
Strand Reverse strand
Band
Transcripts
ENSBTAT00000015586 ENSBTAP00000015586
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0010610 regulation of mRNA stability involved in response to stress
GO:0017148 negative regulation of translation
GO:0070934 CRD-mediated mRNA stabilization
Cellular Component
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0030529 ribonucleoprotein complex
GO:0070937 CRD-mediated mRNA stability complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000159217
View Gene Order
ENSMUSG00000013415
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22166
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL E1BKJ7
UniProt Splice Variant
Entrez Gene 516853
UniGene Bt.27949
RefSeq NM_001192454 XM_005220558
HUGO HGNC:28866
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02049054 DAAA02049055
GenPept
RNA Seq Atlas 516853

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca