InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IGF2BP1

Summary

InnateDB Gene

IDBG-57431.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF2BP1

Gene Name

insulin-like growth factor 2 mRNA binding protein 1

Synonyms

CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1

Species

Homo sapiens

Ensembl Gene

ENSG00000159217

Encoded Proteins

IDBP-57433

insulin-like growth factor 2 mRNA binding protein 1

IDBP-380657

insulin-like growth factor 2 mRNA binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:48997412-49055650

Strand

Forward strand

Band

q21.32

Transcripts

ENST00000290341	ENSP00000290341
ENST00000431824	ENSP00000389135
ENST00000510023
ENST00000515586
ENST00000499130
ENST00000505562

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	63 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0045182	translation regulator activity
GO:0048027	mRNA 5'-UTR binding

Biological Process

GO:0006403	RNA localization
GO:0010467	gene expression
GO:0010610	regulation of mRNA stability involved in response to stress
GO:0017148	negative regulation of translation
GO:0042035	regulation of cytokine biosynthetic process
GO:0051028	mRNA transport
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0030529	ribonucleoprotein complex
GO:0043197	dendritic spine
GO:0048471	perinuclear region of cytoplasm
GO:0070937	CRD-mediated mRNA stability complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000013415

View Gene Order

ENSBTAG00000011736

Not yet available

Pathways

NETPATH

REACTOME

REACT_22166

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.144936 Hs.596290 Hs.738843

RefSeq

NM_001160423 NM_006546 XM_005256955

HUGO

OMIM

CCDS

CCDS11543 CCDS54138

HPRD

09752

IMGT

EMBL

GenPept

RNA Seq Atlas