InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Calcoco2

Summary

InnateDB Gene

IDBG-209835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Calcoco2

Gene Name

calcium binding and coiled-coil domain 2

Synonyms

2410154J16Rik; C77254; Ndp52; Ndp52l1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006056

Encoded Proteins

IDBP-146604

calcium binding and coiled-coil domain 2

IDBP-266144

calcium binding and coiled-coil domain 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22901810

Calcoco2 and Sqstm1 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the Tmem173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes.

InnateDB Annotation from Orthologs

Summary

PMID 19820708

[Homo sapiens] CALCOCO2 recognizes ubiquitin-coated Salmonella enterica in human cells and binds to the adaptor proteins AZI2 and TBKBP1 to recruit TBK1. CALCOCO2 also recruits LC3, an autophagosomal marker, to activate autophagy against bacteria attempting to colonize their cytosol.

PMID 20104023

[Homo sapiens] CALCOCO2 is a novel receptor for the selective autophagy of cytosolic bacteria. CALCOCO2 (NDP52) binds to the bacterial ubiquitin coat as well as to ATG8/LC3 and delivers cytosolic bacteria into autophagosomes.

PMID 19841643

[Homo sapiens] CALCOCO2 directly binds to ubiquitinated bacteria and facilitates the assembly of an autophagic membrane that surrounds bacterial invaders.

PMID 22901810

[Homo sapiens] CALCOCO2 and SQSTM1 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the TMEM173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes. (Demonstrated in mouse)

PMID 23022382

[Homo sapiens] MAP1LC3C (LC3C) and its receptor CALCOCO2 (NDP52) are essential for antibacterial autophagy.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136436:
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:96099326-96111964

Strand

Reverse strand

Band

Transcripts

ENSMUST00000068686	ENSMUSP00000087407
ENSMUST00000097162	ENSMUSP00000103309

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.

Predicted by orthology
Total	70 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0034341	response to interferon-gamma
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000136436

View Gene Order

ENSBTAG00000007935

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

G8JL78

UniProt Splice Variant

Entrez Gene

76815

UniGene

Mm.296049

RefSeq

NM_001271018 XM_006534459 XM_006534460

OMIM

CCDS

CCDS59567

HPRD

IMGT

MGI ID

MGI:1343177

MGI Symbol

Calcoco2

EMBL

AL603682

GenPept

RNA Seq Atlas

102642271 76815