Version 5.4
| Bos taurus Gene: CALCOCO2 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-638886.3 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | CALCOCO2 | ||||||||||||
| Gene Name | Calcium-binding and coiled-coil domain-containing protein 2 | ||||||||||||
| Synonyms | NDP52 | ||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Gene | ENSBTAG00000007935 | ||||||||||||
| Encoded Proteins |
Calcium-binding and coiled-coil domain-containing protein 2
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||
| Summary |
[Homo sapiens] CALCOCO2 recognizes ubiquitin-coated Salmonella enterica in human cells and binds to the adaptor proteins AZI2 and TBKBP1 to recruit TBK1. CALCOCO2 also recruits LC3, an autophagosomal marker, to activate autophagy against bacteria attempting to colonize their cytosol.
[Homo sapiens] CALCOCO2 is a novel receptor for the selective autophagy of cytosolic bacteria. CALCOCO2 (NDP52) binds to the bacterial ubiquitin coat as well as to ATG8/LC3 and delivers cytosolic bacteria into autophagosomes.
[Homo sapiens] CALCOCO2 directly binds to ubiquitinated bacteria and facilitates the assembly of an autophagic membrane that surrounds bacterial invaders.
[Homo sapiens] CALCOCO2 and SQSTM1 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the TMEM173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes. (Demonstrated in mouse)
[Homo sapiens] MAP1LC3C (LC3C) and its receptor CALCOCO2 (NDP52) are essential for antibacterial autophagy.
[Mus musculus] Calcoco2 and Sqstm1 are ubiquitin-autophagy receptors that are required for the recognition of extracelluar bacterial DNA by the Tmem173 (STING)-dependent cytosolic pathway, marking bacteria with ubiquitin, and delivery of bacilli to autophagosomes.
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| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136436:
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 19:38314473-38338074 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | |||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH |
EGFR1 pathway
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| REACTOME | |||||||||||||
| KEGG | |||||||||||||
| INOH | |||||||||||||
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| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | |||||||||||||
| UniGene | Bt.96716 | ||||||||||||
| RefSeq | NM_174400 XM_005220484 XM_005220485 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | |||||||||||||
| GenPept | |||||||||||||
| RNA Seq Atlas | |||||||||||||