Version 5.4
Mus musculus Gene: Sp2
Summary
InnateDB Gene IDBG-210081.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sp2
Gene Name Sp2 transcription factor
Synonyms 4930480I16Rik; mKIAA0048
Species Mus musculus
Ensembl Gene ENSMUSG00000018678
Encoded Proteins
IDBP-210083
Sp2 transcription factor
IDBP-266266
Sp2 transcription factor
IDBP-266268
Sp2 transcription factor
IDBP-266270
Sp2 transcription factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. The protein can act as a transcriptional activator or repressor, depending on the promoter and cell type. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:96953340-96982959
Strand Reverse strand
Band D
Transcripts
ENSMUST00000062652 ENSMUSP00000051403
ENSMUST00000107626 ENSMUSP00000103252
ENSMUST00000107624 ENSMUSP00000103250
ENSMUST00000107623 ENSMUSP00000103249
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0035264 multicellular organism growth
GO:0048144 fibroblast proliferation
GO:0048568 embryonic organ development
GO:0072358 cardiovascular system development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167182
View Gene Order
ENSBTAG00000013740
Not yet available
Cross-References
SwissProt
TrEMBL Q8BNQ4
UniProt Splice Variant
Entrez Gene 78912
UniGene Mm.155547 Mm.490179
RefSeq NM_001080964 NM_030220 XM_006534518 XM_006534519 XM_006534520 XM_006534521
OMIM
CCDS CCDS36291
HPRD
IMGT
MGI ID MGI:1926162
MGI Symbol Sp2
EMBL AK080877 AL596384
GenPept BAC38057
RNA Seq Atlas 78912

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca