Version 5.4
Mus musculus Gene: Procr
Summary
InnateDB Gene IDBG-210683.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Procr
Gene Name protein C receptor, endothelial
Synonyms AI325044; Ccca; Ccd41; Epcr
Species Mus musculus
Ensembl Gene ENSMUSG00000027611
Encoded Proteins
IDBP-210685
protein C receptor, endothelial
IDBP-540718
protein C receptor, endothelial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20543103
[Homo sapiens] PROCR confers anti-inflammatory properties when bound by activated protein C and when PROCR (EPCR) is blocked, F. tularensis loses the ability to suppress the pro-inflammatory response of endothelial cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101000:
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:155751117-155755471
Strand Forward strand
Band H1
Transcripts
ENSMUST00000029140 ENSMUSP00000029140
ENSMUST00000132608 ENSMUSP00000114567
ENSMUST00000155095
ENSMUST00000143493
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0006955 immune response
GO:0007596 blood coagulation
GO:0019882 antigen processing and presentation
GO:0050819 negative regulation of coagulation
Cellular Component
GO:0005813 centrosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101000
View Gene Order
ENSBTAG00000008291
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_235097
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_259461
Common Pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1439
Common Pathway pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_604
Hemostasis pathway
REACT_208597
Cell surface interactions at the vascular wall pathway
REACT_220023
Common Pathway pathway
REACT_212196
Hemostasis pathway
REACT_217138
Formation of Fibrin Clot (Clotting Cascade) pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3243
RefSeq NM_011171
OMIM
CCDS CCDS16954
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca