InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cep250

Summary

InnateDB Gene

IDBG-210743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cep250

Gene Name

centrosomal protein 250

Synonyms

AW490617; B230210E21Rik; Cep2; Inmp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038241

Encoded Proteins

IDBP-210745

centrosomal protein 250

IDBP-210747

centrosomal protein 250

IDBP-261998

centrosomal protein 250

IDBP-262000

centrosomal protein 250

IDBP-536295

centrosomal protein 250

IDBP-532537

centrosomal protein 250

IDBP-532630

centrosomal protein 250

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126001:
This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:155956458-155998900

Strand

Forward strand

Band

Transcripts

ENSMUST00000039994	ENSMUSP00000038255
ENSMUST00000094421	ENSMUSP00000091988
ENSMUST00000109619	ENSMUSP00000105248
ENSMUST00000109618	ENSMUSP00000105247
ENSMUST00000149905
ENSMUST00000151569	ENSMUSP00000114426
ENSMUST00000148191
ENSMUST00000155160
ENSMUST00000156355	ENSMUSP00000122223
ENSMUST00000128683	ENSMUSP00000119845

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007049	cell cycle
GO:0008104	protein localization
GO:0010457	centriole-centriole cohesion
GO:0030997	regulation of centriole-centriole cohesion
GO:0033365	protein localization to organelle

Cellular Component

GO:0005813	centrosome
GO:0005814	centriole
GO:0005929	cilium
GO:0031616	spindle pole centrosome
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome