Version 5.4
Bos taurus Gene: PLEKHA1
Summary
InnateDB Gene IDBG-640567.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHA1
Gene Name pleckstrin homology domain-containing family A member 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004636
Encoded Proteins
IDBP-692849
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107679:
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:42579750-42633511
Strand Forward strand
Band
Transcripts
ENSBTAT00000006081 ENSBTAP00000006081
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0001553 luteinization
GO:0007283 spermatogenesis
GO:0008209 androgen metabolic process
GO:0008210 estrogen metabolic process
GO:0008585 female gonad development
GO:0009791 post-embryonic development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0031529 ruffle organization
GO:0033327 Leydig cell differentiation
GO:0035264 multicellular organism growth
GO:0045184 establishment of protein localization
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048705 skeletal system morphogenesis
GO:0050853 B cell receptor signaling pathway
GO:0051898 negative regulation of protein kinase B signaling
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0070301 cellular response to hydrogen peroxide
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000107679
View Gene Order
ENSMUSG00000040268
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_12
BCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q0IIA5
UniProt Splice Variant
Entrez Gene 513040
UniGene Bt.101365
RefSeq NM_001075593
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122736 DAAA02059451 DAAA02059452
GenPept AAI22737
RNA Seq Atlas 513040

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca