InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HCN4

Summary

InnateDB Gene

IDBG-21086.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCN4

Gene Name

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

Synonyms

SSS2

Species

Homo sapiens

Ensembl Gene

ENSG00000138622

Encoded Proteins

IDBP-21088

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:73319859-73369264

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000261917

ENSP00000261917

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005261	cation channel activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0042802	identical protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002027	regulation of heart rate
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006936	muscle contraction
GO:0007268	synaptic transmission
GO:0008015	blood circulation
GO:0008016	regulation of heart contraction
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071321	cellular response to cGMP
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0031226	intrinsic component of plasma membrane
GO:0043195	terminal bouton

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032338

View Gene Order

ENSBTAG00000017466

Not yet available

Pathways

NETPATH

REACTOME

REACT_13685

Neuronal System pathway

REACT_75862

HCN channels pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9Y3Q4

TrEMBL

UniProt Splice Variant

Entrez Gene

10021

UniGene

Hs.86941

RefSeq

NM_005477

HUGO

HGNC:16882

OMIM

605206

CCDS

CCDS10248

HPRD

09240

IMGT

EMBL

AJ132429 AJ238850

GenPept

CAB42604 CAB52754

RNA Seq Atlas

10021