Version 5.4
Bos taurus Gene: HCN4
Summary
InnateDB Gene IDBG-645641.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCN4
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017466
Encoded Proteins
IDBP-698364
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138622:
This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:19980212-20021927
Strand Reverse strand
Band
Transcripts
ENSBTAT00000023219 ENSBTAP00000023219
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005222 intracellular cAMP activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0002027 regulation of heart rate
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006813 potassium ion transport
GO:0008016 regulation of heart contraction
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031226 intrinsic component of plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000138622
View Gene Order
ENSMUSG00000032338
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_75862
HCN channels pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BIS4
UniProt Splice Variant
Entrez Gene 785689
UniGene Bt.105579
RefSeq XM_002690493 XM_002700513
HUGO HGNC:16882
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02028016
GenPept
RNA Seq Atlas 785689

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca