Version 5.4
Mus musculus Gene: Igfbp4
Summary
InnateDB Gene IDBG-210907.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Igfbp4
Gene Name insulin-like growth factor binding protein 4
Synonyms AI875747; Deb2; IGFBP-4
Species Mus musculus
Ensembl Gene ENSMUSG00000017493
Encoded Proteins
IDBP-210909
insulin-like growth factor binding protein 4
IDBP-718196
IDBP-716980
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141753:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:99041244-99054392
Strand Forward strand
Band D
Transcripts
ENSMUST00000017637 ENSMUSP00000017637
ENSMUST00000130530
ENSMUST00000123946
ENSMUST00000140772 ENSMUSP00000135727
ENSMUST00000177105
ENSMUST00000177092 ENSMUSP00000135112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006954 inflammatory response
GO:0010906 regulation of glucose metabolic process
GO:0040008 regulation of growth
GO:0043410 positive regulation of MAPK cascade
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044342 type B pancreatic cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141753
View Gene Order
ENSBTAG00000008611
Not yet available
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_235886
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
REACT_206584
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_213782
Metabolism of proteins pathway
KEGG
INOH
INOH website
IGF1 signaling pathway pathway
PID NCI
wnt_signaling_pathway
Wnt signaling network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.233799
RefSeq NM_010517
OMIM
CCDS CCDS25371
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca