Version 5.4
Mus musculus Gene: Dock1
Summary
InnateDB Gene IDBG-211315.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dock1
Gene Name dedicator of cytokinesis 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000058325
Encoded Proteins
IDBP-211317
dedicator of cytokinesis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150760:
This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis. [provided by RefSeq, Jul 2008]
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:134670687-135173639
Strand Forward strand
Band F3
Transcripts
ENSMUST00000084488 ENSMUSP00000081531
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0017124 SH3 domain binding
GO:0020037 heme binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0007264 small GTPase mediated signal transduction
GO:0016477 cell migration
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000150760
View Gene Order
ENSBTAG00000031890
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_224553
Hemostasis pathway
REACT_229826
Netrin-1 signaling pathway
REACT_227951
Signaling by VEGF pathway
REACT_230745
Immune System pathway
REACT_248291
DCC mediated attractive signaling pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
mmu04510
Focal adhesion pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
HGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_22351
DCC mediated attractive signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04510
Focal adhesion pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
HGF signaling pathway pathway
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
netrin_pathway
Netrin-mediated signaling events
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
Cross-References
SwissProt Q8BUR4
TrEMBL
UniProt Splice Variant
Entrez Gene 330662
UniGene Mm.397428 Mm.408024 Mm.436572
RefSeq NM_001033420
OMIM
CCDS CCDS40166
HPRD
IMGT
MGI ID MGI:2429765
MGI Symbol Dock1
EMBL AC100208 AC127574 AC129300 AC136515 AC136641 AK078899 AK082835 AK134905 AK141224 BC006755 BC009668 BC058998 BC098214
GenPept AAH06755 AAH09668 AAH58998 AAH98214 BAC37448 BAC38645 BAE22333 BAE24599
RNA Seq Atlas 330662

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca