Bos taurus Gene: DOCK1 | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-640952.3 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | DOCK1 | ||||||||||||
Gene Name | Uncharacterized protein | ||||||||||||
Synonyms | DOCK180 | ||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Gene | ENSBTAG00000031890 | ||||||||||||
Encoded Proteins |
dedicator of cytokinesis 1
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150760:
This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis. [provided by RefSeq, Jul 2008] This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 26:46791127-47295654 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | |||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH |
EGFR1 pathway
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REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Factors involved in megakaryocyte development and platelet production pathway
DCC mediated attractive signaling pathway
Netrin-1 signaling pathway
Developmental Biology pathway
Signaling by VEGF pathway
Innate Immune System pathway
Axon guidance pathway
Signal Transduction pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Hemostasis pathway
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Hemostasis pathway
Netrin-1 signaling pathway
Signaling by VEGF pathway
Immune System pathway
DCC mediated attractive signaling pathway
Factors involved in megakaryocyte development and platelet production pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Developmental Biology pathway
Signal Transduction pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
Bacterial invasion of epithelial cells pathway
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INOH |
Integrin signaling pathway pathway
HGF signaling pathway pathway
Integrin signaling pathway pathway
HGF signaling pathway pathway
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PID NCI |
Regulation of RAC1 activity
Netrin-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Signaling events mediated by focal adhesion kinase
Neurotrophic factor-mediated Trk receptor signaling
Alpha4 beta1 integrin signaling events
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Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | F1MIX6 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 537203 | ||||||||||||
UniGene | Bt.30953 | ||||||||||||
RefSeq | XM_002698580 | ||||||||||||
HUGO | HGNC:2987 | ||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | DAAA02059558 DAAA02059559 DAAA02059560 DAAA02059561 DAAA02059562 DAAA02059563 DAAA02059564 DAAA02059565 DAAA02059566 | ||||||||||||
GenPept | |||||||||||||
RNA Seq Atlas | 537203 | ||||||||||||