Version 5.4
Mus musculus Gene: Glrx3
Summary
InnateDB Gene IDBG-211431.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Glrx3
Gene Name glutaredoxin 3
Synonyms PICOT; Txnl2
Species Mus musculus
Ensembl Gene ENSMUSG00000031068
Encoded Proteins
IDBP-211433
glutaredoxin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108010:
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:137437648-137468594
Strand Forward strand
Band F4
Transcripts
ENSMUST00000064404 ENSMUSP00000066621
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0007067 mitotic nuclear division
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005681 spliceosomal complex
GO:0005938 cell cortex
GO:0030018 Z disc
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108010
View Gene Order
ENSBTAG00000005027
Not yet available
Cross-References
SwissProt Q9CQM9
TrEMBL
UniProt Splice Variant
Entrez Gene 30926
UniGene
RefSeq NM_023140
OMIM
CCDS CCDS21948
HPRD
IMGT
MGI ID MGI:1353653
MGI Symbol Glrx3
EMBL AF118650 AK010354 AK017371 AK147158 AK152446 AK152634 AK155190 AK167672 BC033506 BC087885
GenPept AAF28842 AAH33506 AAH87885 BAB26874 BAB30712 BAE27724 BAE31225 BAE31376 BAE33105 BAE39721
RNA Seq Atlas 30926

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca