Version 5.4
Bos taurus Gene: GLRX3
Summary
InnateDB Gene IDBG-641075.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLRX3
Gene Name glutaredoxin-3
Synonyms PICOT; TXNL2
Species Bos taurus
Ensembl Gene ENSBTAG00000005027
Encoded Proteins
IDBP-693400
glutaredoxin-3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108010:
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:49742225-49773421
Strand Forward strand
Band
Transcripts
ENSBTAT00000006613 ENSBTAP00000006613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0007067 mitotic nuclear division
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005681 spliceosomal complex
GO:0030018 Z disc
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000108010
View Gene Order
ENSMUSG00000031068
View Gene Order
Cross-References
SwissProt
TrEMBL F1ML12
UniProt Splice Variant
Entrez Gene 511528
UniGene
RefSeq NM_001035101
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02059617
GenPept
RNA Seq Atlas 511528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca