Version 5.4
| Homo sapiens Gene: GNRHR | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-21148.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | GNRHR | ||||||||||||||||||
| Gene Name | gonadotropin-releasing hormone receptor | ||||||||||||||||||
| Synonyms | GNRHR1; GRHR; HH7; LHRHR; LRHR | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000109163 | ||||||||||||||||||
| Encoded Proteins |
gonadotropin-releasing hormone receptor
gonadotropin-releasing hormone receptor
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008] This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5\' region and multiple polyA signals in the 3\' region have been identified for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 4:67739328-67754360 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Hormone ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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| KEGG |
GnRH signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P30968 | ||||||||||||||||||
| TrEMBL | V9GZN9 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 2798 | ||||||||||||||||||
| UniGene | Hs.407587 | ||||||||||||||||||
| RefSeq | NM_001012763 NM_000406 | ||||||||||||||||||
| HUGO | HGNC:4421 | ||||||||||||||||||
| OMIM | 138850 | ||||||||||||||||||
| CCDS | CCDS47064 CCDS3517 | ||||||||||||||||||
| HPRD | 00732 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF001950 AF001951 AF001952 AY392011 BC113546 L03380 L07949 S60587 S77472 U19603 Z81148 Z99995 | ||||||||||||||||||
| GenPept | AAA35917 AAA35918 AAA63885 AAB26287 AAB33884 AAB71348 AAI13547 AAR92228 CAB03541 CAB17082 | ||||||||||||||||||
| RNA Seq Atlas | 2798 | ||||||||||||||||||