InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dhx58

Summary

InnateDB Gene

IDBG-211512.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhx58

Gene Name

DEXH (Asp-Glu-X-His) box polypeptide 58

Synonyms

B430001I08Rik; D11Lgp2e; Lgp2; LPG2; RLR-3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017830

Encoded Proteins

IDBP-211514

DEXH (Asp-Glu-X-His) box polypeptide 58

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24434553

Cytotoxic stress exemplified by ionizing radiation induces IFN-beta and enhances the expression of Dhx58 which in turn suppresses the interferon stimulated genes associated with cytotoxic stress by turning off the expression of IFN-beta.

InnateDB Annotation from Orthologs

Summary

PMID 17190814

[Homo sapiens] DHX58 (LGP2) helicase is related to DDX58 (RIG-I) and IFIH1 (MDA5) but lacks caspase activation and recruitment domains (CARDs), and functions as a negative regulator of innate host defence.

PMID 16210631

[Homo sapiens] DHX58 lacks the caspase recruitment domain (CARD) homology and functions as a negative regulator by interfering with the recognition of viral RNA by DDX58 (RIG-I) and IFIH1 (MDA5).

PMID 16116171

[Homo sapiens] DHX58 functions as a negative regulator of antiviral innate immunity by interfering with the recognition of viral RNA by DDX58 (RIG-I) and IFIH1 (MDA5).

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108771:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:100694884-100704271

Strand

Reverse strand

Band

Transcripts

ENSMUST00000017974	ENSMUSP00000017974
ENSMUST00000140543
ENSMUST00000149869
ENSMUST00000126167
ENSMUST00000150656
ENSMUST00000132930

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003725	double-stranded RNA binding
GO:0003727	single-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016817	hydrolase activity, acting on acid anhydrides

Biological Process

GO:0008152	metabolic process
GO:0009615	response to virus
GO:0032480	negative regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0039534	negative regulation of MDA-5 signaling pathway
GO:0039536	negative regulation of RIG-I signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0045824	negative regulation of innate immune response
GO:0051607	defense response to virus
GO:1900245	positive regulation of MDA-5 signaling pathway
GO:1900246	positive regulation of RIG-I signaling pathway

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000108771

View Gene Order

ENSBTAG00000046580

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04622

RIG-I-like receptor signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25359

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04622

RIG-I-like receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.271830

RefSeq

NM_030150

OMIM

CCDS

CCDS25431

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas