Version 5.4
Homo sapiens Gene: DHX58
Summary
InnateDB Gene IDBG-50252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHX58
Gene Name DEXH (Asp-Glu-X-His) box polypeptide 58
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000108771
Encoded Proteins
IDBP-50254
DEXH (Asp-Glu-X-His) box polypeptide 58
IDBP-378529
DEXH (Asp-Glu-X-His) box polypeptide 58
IDBP-378532
DEXH (Asp-Glu-X-His) box polypeptide 58
IDBP-758445
IDBP-762394
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17190814
DHX58 (LGP2) helicase is related to DDX58 (RIG-I) and IFIH1 (MDA5) but lacks caspase activation and recruitment domains (CARDs), and functions as a negative regulator of innate host defence.
PMID 16210631
DHX58 lacks the caspase recruitment domain (CARD) homology and functions as a negative regulator by interfering with the recognition of viral RNA by DDX58 (RIG-I) and IFIH1 (MDA5).
PMID 16116171
DHX58 functions as a negative regulator of antiviral innate immunity by interfering with the recognition of viral RNA by DDX58 (RIG-I) and IFIH1 (MDA5).
InnateDB Annotation from Orthologs
Summary
PMID 24434553
[Mus musculus] Cytotoxic stress exemplified by ionizing radiation induces IFN-beta and enhances the expression of Dhx58 which in turn suppresses the interferon stimulated genes associated with cytotoxic stress by turning off the expression of IFN-beta.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42101404-42112733
Strand Reverse strand
Band q21.2
Transcripts
ENST00000251642 ENSP00000251642
ENST00000413196 ENSP00000416389
ENST00000430773 ENSP00000404639
ENST00000590637
ENST00000589979 ENSP00000467470
ENST00000592024
ENST00000586522
ENST00000591220 ENSP00000466721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
Biological Process
GO:0008152 metabolic process
GO:0009615 response to virus
GO:0016032 viral process
GO:0032480 negative regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0039534 negative regulation of MDA-5 signaling pathway
GO:0039536 negative regulation of RIG-I signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
GO:0045824 negative regulation of innate immune response
GO:0051607 defense response to virus
GO:1900245 positive regulation of MDA-5 signaling pathway
GO:1900246 positive regulation of RIG-I signaling pathway
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017830
View Gene Order
ENSBTAG00000046580
Not yet available
Pathways
NETPATH
REACTOME
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JE76
UniProt Splice Variant
Entrez Gene 79132
UniGene Hs.55918
RefSeq NM_024119
HUGO HGNC:29517
OMIM 608588
CCDS CCDS11416
HPRD 13115
IMGT
EMBL AC105024
GenPept
RNA Seq Atlas 79132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca