InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HCRT

Summary

InnateDB Gene

IDBG-50472.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCRT

Gene Name

hypocretin (orexin) neuropeptide precursor

Synonyms

NRCLP1; OX; PPOX

Species

Homo sapiens

Ensembl Gene

ENSG00000161610

Encoded Proteins

IDBP-50474

hypocretin (orexin) neuropeptide precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:42184060-42185452

Strand

Reverse strand

Band

q21.2

Transcripts

ENST00000293330

ENSP00000293330

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031771	type 1 hypocretin receptor binding
GO:0031772	type 2 hypocretin receptor binding

Biological Process

GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007631	feeding behavior
GO:0008156	negative regulation of DNA replication
GO:0042755	eating behavior
GO:0043267	negative regulation of potassium ion transport
GO:0046928	regulation of neurotransmitter secretion
GO:0051928	positive regulation of calcium ion transport
GO:0051970	negative regulation of transmission of nerve impulse
GO:0051971	positive regulation of transmission of nerve impulse
GO:0060079	regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030141	secretory granule
GO:0048471	perinuclear region of cytoplasm