InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Taldo1

Summary

InnateDB Gene

IDBG-212181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taldo1

Gene Name

transaldolase 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025503

Encoded Proteins

IDBP-212183

transaldolase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a key enzyme of the nonoxidative pentose phosphate pathway that provides ribose-5-phosphate for nucleic acid synthesis and nicotinamide adenine dinucleotide phosphate (NADPH) for lipid biosynthesis. The encoded protein is important for maintaining structure and function of mitochondria. Studies in knockout mice identify that deficiency of this gene product is a cause of sperm dysmotility and male infertility. Deficiency of this protein has also been identified as a cause of hepatocarcinogenesis in mice. Two related pseudogenes have been identified on chromosome 10. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:141392199-141402968

Strand

Forward strand

Band

Transcripts

ENSMUST00000026576	ENSMUSP00000026576
ENSMUST00000141793
ENSMUST00000125597

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004801	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
GO:0048029	monosaccharide binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006098	pentose-phosphate shunt
GO:0009052	pentose-phosphate shunt, non-oxidative branch
GO:0019682	glyceraldehyde-3-phosphate metabolic process