Homo sapiens Gene: TALDO1
Summary
InnateDB Gene IDBG-17874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TALDO1
Gene Name transaldolase 1
Synonyms TAL; TAL-H; TALDOR; TALH
Species Homo sapiens
Ensembl Gene ENSG00000177156
Encoded Proteins
transaldolase 1
transaldolase 1
transaldolase 1
transaldolase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:747329-765024
Strand Forward strand
Band p15.5
Transcripts
ENST00000319006 ENSP00000321259
ENST00000528070 ENSP00000435042
ENST00000532685
ENST00000528097 ENSP00000437098
ENST00000530440 ENSP00000433501
ENST00000530119
ENST00000533796
ENST00000530666
ENST00000532202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004801 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005999 xylulose biosynthetic process
GO:0006098 pentose-phosphate shunt
GO:0006112 energy reserve metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Pentose phosphate pathway (hexose monophosphate shunt) pathway
Insulin effects increased synthesis of Xylulose-5-Phosphate pathway
Integration of energy metabolism pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Metabolism pathway
Disease pathway
Glycogen storage diseases pathway
KEGG
Pentose phosphate pathway pathway
INOH
Pentose phosphate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006755
HUGO
OMIM
CCDS CCDS7712
HPRD 03640
IMGT
EMBL
GenPept
RNA Seq Atlas