Version 5.4
Mus musculus Gene: Eya2
Summary
InnateDB Gene IDBG-212752.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eya2
Gene Name eyes absent 2 homolog (Drosophila)
Synonyms Eab1
Species Mus musculus
Ensembl Gene ENSMUSG00000017897
Encoded Proteins
IDBP-212758
eyes absent 2 homolog (Drosophila)
IDBP-212760
eyes absent 2 homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the eyes absent protein family. The encoded protein is a tyrosine phosphatase which acts as a transcriptional activator during development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:165595032-165771727
Strand Forward strand
Band H3
Transcripts
ENSMUST00000063433 ENSMUSP00000066244
ENSMUST00000088132 ENSMUSP00000085455
ENSMUST00000150669
ENSMUST00000150638
ENSMUST00000128696
ENSMUST00000128280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0007275 multicellular organismal development
GO:0014706 striated muscle tissue development
GO:0016576 histone dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097345 mitochondrial outer membrane permeabilization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000064655
View Gene Order
ENSBTAG00000013336
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.282719
RefSeq NM_001271962 NM_001271963 NM_010165 XM_006498737 XM_006498739
OMIM
CCDS CCDS17084
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca