Version 5.4
Mus musculus Gene: Stau1
Summary
InnateDB Gene IDBG-212962.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stau1
Gene Name staufen (RNA binding protein) homolog 1 (Drosophila)
Synonyms 5830401L18Rik; AW549911; C85792; Stau
Species Mus musculus
Ensembl Gene ENSMUSG00000039536
Encoded Proteins
IDBP-212964
staufen (RNA binding protein) homolog 1 (Drosophila)
IDBP-262817
staufen (RNA binding protein) homolog 1 (Drosophila)
IDBP-262819
staufen (RNA binding protein) homolog 1 (Drosophila)
IDBP-262821
staufen (RNA binding protein) homolog 1 (Drosophila)
IDBP-788136
staufen (RNA binding protein) homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124214:
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5\'UTR. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:166947549-166996299
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000049412 ENSMUSP00000042626
ENSMUST00000109238 ENSMUSP00000104861
ENSMUST00000109236 ENSMUSP00000104859
ENSMUST00000109235 ENSMUSP00000104858
ENSMUST00000142481
ENSMUST00000149454
ENSMUST00000134664
ENSMUST00000154506
ENSMUST00000130790
ENSMUST00000130104
ENSMUST00000184390 ENSMUSP00000139039
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0008157 protein phosphatase 1 binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008298 intracellular mRNA localization
Cellular Component
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0030425 dendrite
GO:0030529 ribonucleoprotein complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124214
View Gene Order
ENSBTAG00000000241
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.431872 Mm.486384 Mm.487146 Mm.73276
RefSeq NM_001109905 NM_001109906 NM_001291160 NM_011490 XM_006499071 XM_006499072 XM_006499073
OMIM
CCDS CCDS17093 CCDS50800 CCDS50801 CCDS71197
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca