Version 5.4
Bos taurus Gene: GH1
Summary
InnateDB Gene IDBG-641755.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GH1
Gene Name Somatotropin
Synonyms GH
Species Bos taurus
Ensembl Gene ENSBTAG00000017220
Encoded Proteins
IDBP-694168
Somatotropin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000259384:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:48768618-48772014
Strand Reverse strand
Band
Transcripts
ENSBTAT00000022885 ENSBTAP00000022885
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.
Predicted by orthology
Total 72 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005131 growth hormone receptor binding
GO:0005179 hormone activity
GO:0046872 metal ion binding
Biological Process
GO:0032094 response to food
GO:0032869 cellular response to insulin stimulus
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway
GO:0040018 positive regulation of multicellular organism growth
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0030141 secretory granule
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000020713
View Gene Order
ENSG00000259384
View Gene Order
Pathways
NETPATH
REACTOME
REACT_210701
Peptide hormone metabolism pathway
REACT_216183
Signaling by ERBB4 pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_223503
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_213138
Immune System pathway
REACT_214353
Signal Transduction pathway
REACT_219151
Prolactin receptor signaling pathway
REACT_213782
Metabolism of proteins pathway
REACT_209393
Growth hormone receptor signaling pathway
REACT_220588
Nuclear signaling by ERBB4 pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_198574
Nuclear signaling by ERBB4 pathway
REACT_198561
Prolactin receptor signaling pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_233293
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_198614
Growth hormone receptor signaling pathway
REACT_188257
Signal Transduction pathway
REACT_111133
Growth hormone receptor signaling pathway
REACT_115697
Prolactin receptor signaling pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_19189
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_111102
Signal Transduction pathway
REACT_17015
Metabolism of proteins pathway
REACT_6900
Immune System pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
mmu04630
Jak-STAT signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
Growth hormone signaling pathway
INOH website
GPCR signaling pathway
INOH website
Growth hormone signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P01246
TrEMBL A4LAP1 B0FPG6 D8MIT8 G4XKY3 I6WN98 Q9N264
UniProt Splice Variant
Entrez Gene 280804
UniGene Bt.28019
RefSeq NM_180996 XM_005220810 XM_005220812 XM_005220813
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF034386 AF117350 DQ184480 EF451795 EF451796 EF470979 EU344992 EU344993 FN994193 J00008 JF826521 JQ711182 M11558 M23813 M27325 M57764 V00111
GenPept AAA30542 AAA30543 AAA30544 AAA30545 AAA30556 AAB92549 AAF28806 ABA26924 ABO21739 ABO21740 ABO64651 ABY61240 ABY61241 AEP25784 AFN44376 CAA23445 CBN80512
RNA Seq Atlas 280804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca