InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EDN3

Summary

InnateDB Gene

IDBG-641126.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDN3

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012109

Encoded Proteins

IDBP-693455

endothelin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124205:
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:57571799-57596875

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000053897

ENSBTAP00000052537

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0001755	neural crest cell migration
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0003100	regulation of systemic arterial blood pressure by endothelin
GO:0007166	cell surface receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010460	positive regulation of heart rate
GO:0014826	vein smooth muscle contraction
GO:0019229	regulation of vasoconstriction
GO:0030072	peptide hormone secretion
GO:0030182	neuron differentiation
GO:0030318	melanocyte differentiation
GO:0030334	regulation of cell migration
GO:0030593	neutrophil chemotaxis
GO:0042310	vasoconstriction
GO:0043406	positive regulation of MAP kinase activity
GO:0045840	positive regulation of mitosis
GO:0046887	positive regulation of hormone secretion
GO:0048016	inositol phosphate-mediated signaling
GO:0048070	regulation of developmental pigmentation