InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ss18l1

Summary

InnateDB Gene

IDBG-213743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ss18l1

Gene Name

synovial sarcoma translocation gene on chromosome 18-like 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039086

Encoded Proteins

IDBP-213745

synovial sarcoma translocation gene on chromosome 18-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184402:
Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L1 gene is homologous to SS18.[supplied by OMIM, Jul 2002]
This gene encodes a calcium-responsive transactivator which is an essential subunit of a neuron-specific chromatin-remodeling complex. The structure of this gene is similar to that of the SS18 gene. Mutations in this gene are involved in amyotrophic lateral sclerosis (ALS). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:180042509-180070201

Strand

Forward strand

Band

Transcripts

ENSMUST00000041126

ENSMUSP00000041288

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016358	dendrite development
GO:0016568	chromatin modification
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050773	regulation of dendrite development

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0005634	nucleus
GO:0016604	nuclear body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000184402

View Gene Order

ENSBTAG00000014438

Not yet available

Cross-References

SwissProt

Q8BW22

TrEMBL

UniProt Splice Variant

Entrez Gene

269397

UniGene

Mm.490644 Mm.63068

RefSeq

NM_178750 XM_006500631 XM_006500632

OMIM

CCDS

CCDS17167

HPRD

IMGT

MGI ID

MGI:2444061

MGI Symbol

Ss18l1

EMBL

AK038669 AK054560 AK133944 AK173004 AL663067 BC053087 BC054730

GenPept

AAH53087 AAH54730 BAC30089 BAC35824 BAD32282 BAE21942 CAM18353

RNA Seq Atlas

269397