InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wipi1

Summary

InnateDB Gene

IDBG-213834.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wipi1

Gene Name

WD repeat domain, phosphoinositide interacting 1

Synonyms

4930533H01Rik; AW411817; D11Ertd498e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041895

Encoded Proteins

IDBP-213836

WD repeat domain, phosphoinositide interacting 1

IDBP-213840

WD repeat domain, phosphoinositide interacting 1

IDBP-268247

WD repeat domain, phosphoinositide interacting 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070540:
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:109573331-109611967

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103060	ENSMUSP00000099349
ENSMUST00000047186	ENSMUSP00000038635
ENSMUST00000106689	ENSMUSP00000102300
ENSMUST00000153738

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0030331	estrogen receptor binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0050681	androgen receptor binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006914	autophagy
GO:0048203	vesicle targeting, trans-Golgi to endosome

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0000421	autophagic vacuole membrane
GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0010008	endosome membrane
GO:0030136	clathrin-coated vesicle
GO:0034045	pre-autophagosomal structure membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000070540

View Gene Order

ENSBTAG00000039556

Not yet available

Pathways

NETPATH

REACTOME

REACT_239697

Unfolded Protein Response (UPR) pathway

REACT_247926

Metabolism of proteins pathway

REACT_231085

IRE1alpha activates chaperones pathway

REACT_106572

XBP1(S) activates chaperone genes pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_18273

XBP1(S) activates chaperone genes pathway

REACT_18368

IRE1alpha activates chaperones pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_17015

Metabolism of proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.35817 Mm.410421

RefSeq

NM_145940

OMIM

CCDS

CCDS25582

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas