InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WIPI1

Summary

InnateDB Gene

IDBG-65866.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WIPI1

Gene Name

WD repeat domain, phosphoinositide interacting 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000070540

Encoded Proteins

IDBP-65868

WD repeat domain, phosphoinositide interacting 1

IDBP-603405

WD repeat domain, phosphoinositide interacting 1

IDBP-762994

IDBP-764807

IDBP-762529

IDBP-760914

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:68420948-68457513

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000262139	ENSP00000262139
ENST00000546360	ENSP00000437345
ENST00000592645	ENSP00000465695
ENST00000589316	ENSP00000465470
ENST00000590402
ENST00000585393	ENSP00000465557
ENST00000587731
ENST00000591744	ENSP00000466270
ENST00000589459
ENST00000586815
ENST00000591494

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0030331	estrogen receptor binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0050681	androgen receptor binding
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Biological Process

GO:0006914	autophagy
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0048203	vesicle targeting, trans-Golgi to endosome

Cellular Component

GO:0000139	Golgi membrane
GO:0000407	pre-autophagosomal structure
GO:0000421	autophagic vacuole membrane
GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0005856	cytoskeleton
GO:0010008	endosome membrane
GO:0030136	clathrin-coated vesicle
GO:0034045	pre-autophagosomal structure membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041895

View Gene Order

ENSBTAG00000039556

Not yet available

Pathways

NETPATH

REACTOME

REACT_18273

XBP1(S) activates chaperone genes pathway

REACT_18368

IRE1alpha activates chaperones pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_17015

Metabolism of proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.463964

RefSeq

NM_017983 XM_005257497

HUGO

OMIM

CCDS

CCDS11677

HPRD

08540

IMGT

EMBL

GenPept

RNA Seq Atlas