InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KCNJ2

Summary

InnateDB Gene

IDBG-643567.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ2

Gene Name

Inward rectifier potassium channel 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008294

Encoded Proteins

IDBP-696128

Inward rectifier potassium channel 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123700:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:61185603-61195897

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000010914

ENSBTAP00000010914

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0042802	identical protein binding
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0010107	potassium ion import
GO:0014861	regulation of skeletal muscle contraction via regulation of action potential
GO:0015693	magnesium ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0051289	protein homotetramerization
GO:0055119	relaxation of cardiac muscle
GO:0060306	regulation of membrane repolarization
GO:0071805	potassium ion transmembrane transport
GO:0086001	cardiac muscle cell action potential
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086011	membrane repolarization during action potential
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:0090076	relaxation of skeletal muscle