Version 5.4
Homo sapiens Gene: GPBP1
Summary
InnateDB Gene IDBG-22387.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPBP1
Gene Name GC-rich promoter binding protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000062194
Encoded Proteins
IDBP-22391
GC-rich promoter binding protein 1
IDBP-368083
GC-rich promoter binding protein 1
IDBP-475892
GC-rich promoter binding protein 1
IDBP-483062
GC-rich promoter binding protein 1
IDBP-477916
GC-rich promoter binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:57173948-57264679
Strand Forward strand
Band q11.2
Transcripts
ENST00000309096
ENST00000264779 ENSP00000264779
ENST00000424459 ENSP00000401596
ENST00000514387 ENSP00000421709
ENST00000506184 ENSP00000421202
ENST00000511209 ENSP00000422337
ENST00000513732
ENST00000513524
ENST00000515484
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032745
View Gene Order
ENSBTAG00000012124
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444279 Hs.694984
RefSeq NM_001127235 NM_001127236 NM_001203246 NM_022913 XM_005248571 XM_005248572 XM_005248573 XM_005248574 XM_006714673 XM_006714674
HUGO
OMIM
CCDS CCDS34162 CCDS47211 CCDS47212 CCDS56368
HPRD 16333
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca