Version 5.4
Homo sapiens Gene: TUFM
Summary
InnateDB Gene IDBG-23469.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUFM
Gene Name Tu translation elongation factor, mitochondrial
Synonyms COXPD4; EF-TuMT; EFTU; P43
Species Homo sapiens
Ensembl Gene ENSG00000178952
Encoded Proteins
IDBP-23471
Tu translation elongation factor, mitochondrial
IDBP-746362
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22749352
TUFM inhibits RLR-induced IFN-I and promotes autophagy during viral infection.
InnateDB Annotation from Orthologs
Summary
PMID 22749352
[Mus musculus] Tufm inhibits RLR-induced IFN-I and promotes autophagy during viral infection. (Demonstrated in human)
Entrez Gene
Summary This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:28842411-28846408
Strand Reverse strand
Band p11.2
Transcripts
ENST00000313511 ENSP00000322439
ENST00000569217
ENST00000565012 ENSP00000455007
ENST00000561644
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 135 [view]
Protein-Protein 135 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006414 translational elongation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0042645 mitochondrial nucleoid
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073838
View Gene Order
ENSBTAG00000019216
Not yet available
Pathways
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267677
Mitochondrial translation elongation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.12084
RefSeq NM_003321
HUGO
OMIM
CCDS CCDS10642
HPRD 03861
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca