InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TUFM

Summary

InnateDB Gene

IDBG-638969.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TUFM

Gene Name

Elongation factor Tu, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019216

Encoded Proteins

IDBP-691083

Elongation factor Tu, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22749352

[Homo sapiens] TUFM inhibits RLR-induced IFN-I and promotes autophagy during viral infection.

PMID 22749352

[Mus musculus] Tufm inhibits RLR-induced IFN-I and promotes autophagy during viral infection. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178952:
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:26225846-26229801

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025586

ENSBTAP00000025586

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	85 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0006414	translational elongation

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome