Version 5.4
Homo sapiens Gene: CRH
Summary
InnateDB Gene IDBG-23777.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRH
Gene Name corticotropin releasing hormone
Synonyms CRF
Species Homo sapiens
Ensembl Gene ENSG00000147571
Encoded Proteins
IDBP-23779
corticotropin releasing hormone
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:66176382-66178725
Strand Reverse strand
Band q13.1
Transcripts
ENST00000276571 ENSP00000276571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
GO:0017045 corticotropin-releasing hormone activity
GO:0051430 corticotropin-releasing hormone receptor 1 binding
GO:0051431 corticotropin-releasing hormone receptor 2 binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0001963 synaptic transmission, dopaminergic
GO:0006704 glucocorticoid biosynthetic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0007565 female pregnancy
GO:0007567 parturition
GO:0007611 learning or memory
GO:0007616 long-term memory
GO:0007631 feeding behavior
GO:0008202 steroid metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008306 associative learning
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010700 negative regulation of norepinephrine secretion
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness
GO:0010942 positive regulation of cell death
GO:0014062 regulation of serotonin secretion
GO:0016101 diterpenoid metabolic process
GO:0021854 hypothalamus development
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0032811 negative regulation of epinephrine secretion
GO:0033685 negative regulation of luteinizing hormone secretion
GO:0035641 locomotory exploration behavior
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035902 response to immobilization stress
GO:0042220 response to cocaine
GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep
GO:0042493 response to drug
GO:0043627 response to estrogen
GO:0045471 response to ethanol
GO:0045472 response to ether
GO:0045776 negative regulation of blood pressure
GO:0048265 response to pain
GO:0050801 ion homeostasis
GO:0051412 response to corticosterone
GO:0051461 positive regulation of corticotropin secretion
GO:0051464 positive regulation of cortisol secretion
GO:0051602 response to electrical stimulus
GO:0060291 long-term synaptic potentiation
GO:0060456 positive regulation of digestive system process
GO:0060548 negative regulation of cell death
GO:0070093 negative regulation of glucagon secretion
GO:0071314 cellular response to cocaine
GO:0071549 cellular response to dexamethasone stimulus
GO:0090280 positive regulation of calcium ion import
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000854 positive regulation of corticosterone secretion
GO:2000987 positive regulation of behavioral fear response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0043025 neuronal cell body
GO:0043196 varicosity
GO:0043204 perikaryon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049796
View Gene Order
ENSBTAG00000033128
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04730
Long-term depression pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
rapid_gr_pathway
Rapid glucocorticoid signaling
Cross-References
SwissProt P06850
TrEMBL
UniProt Splice Variant
Entrez Gene 1392
UniGene Hs.75294
RefSeq NM_000756
HUGO HGNC:2355
OMIM 122560
CCDS CCDS6188
HPRD
IMGT
EMBL AK075431 BC002599 BC011031 BT007453 CH471068 V00571
GenPept AAH02599 AAH11031 AAP36121 BAG52136 CAA23834 EAW86897
RNA Seq Atlas 1392

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca