InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HGF

Summary

InnateDB Gene

IDBG-24150.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HGF

Gene Name

hepatocyte growth factor (hepapoietin A; scatter factor)

Synonyms

DFNB39; F-TCF; HGFB; HPTA; SF

Species

Homo sapiens

Ensembl Gene

ENSG00000019991

Encoded Proteins

IDBP-24152

hepatocyte growth factor (hepapoietin A; scatter factor)

IDBP-24154

hepatocyte growth factor (hepapoietin A; scatter factor)

IDBP-380445

hepatocyte growth factor (hepapoietin A; scatter factor)

IDBP-380446

hepatocyte growth factor (hepapoietin A; scatter factor)

IDBP-380448

hepatocyte growth factor (hepapoietin A; scatter factor)

IDBP-380449

hepatocyte growth factor (hepapoietin A; scatter factor)

IDBP-380451

hepatocyte growth factor (hepapoietin A; scatter factor)

IDBP-380453

hepatocyte growth factor (hepapoietin A; scatter factor)

IDBP-380454

hepatocyte growth factor (hepapoietin A; scatter factor)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:81699006-81770438

Strand

Reverse strand

Band

q21.11

Transcripts

ENST00000222390	ENSP00000222390
ENST00000354224	ENSP00000346164
ENST00000457544	ENSP00000391238
ENST00000444829	ENSP00000389854
ENST00000453411	ENSP00000408270
ENST00000423064	ENSP00000413829
ENST00000453018	ENSP00000395468
ENST00000412881	ENSP00000396307
ENST00000421558	ENSP00000388592
ENST00000465234

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0000902	cell morphogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0001889	liver development
GO:0002576	platelet degranulation
GO:0006508	proteolysis
GO:0007067	mitotic nuclear division
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168	platelet activation
GO:0030212	hyaluronan metabolic process
GO:0030335	positive regulation of cell migration
GO:0031100	organ regeneration
GO:0031643	positive regulation of myelination
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045669	positive regulation of osteoblast differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0051450	myoblast proliferation
GO:0060326	cell chemotaxis
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0070572	positive regulation of neuron projection regeneration
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000573	positive regulation of DNA biosynthetic process