Version 5.4
Homo sapiens Gene: SUPT4H1
Summary
InnateDB Gene IDBG-244315.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUPT4H1
Gene Name suppressor of Ty 4 homolog 1 (S. cerevisiae)
Synonyms SPT4; SPT4H; SUPT4H
Species Homo sapiens
Ensembl Gene ENSG00000213246
Encoded Proteins
IDBP-61126
suppressor of Ty 4 homolog 1 (S. cerevisiae)
IDBP-762008
IDBP-763799
IDBP-764892
IDBP-758244
IDBP-760038
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:58345175-58353093
Strand Reverse strand
Band q22
Transcripts
ENST00000225504 ENSP00000225504
ENST00000577396 ENSP00000462100
ENST00000581204
ENST00000580947 ENSP00000462670
ENST00000581166 ENSP00000463979
ENST00000579289 ENSP00000462602
ENST00000581540 ENSP00000464618
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0016032 viral process
GO:0032785 negative regulation of DNA-dependent transcription, elongation
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050434 positive regulation of viral transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0032044 DSIF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020485
View Gene Order
ENSBTAG00000003386
Not yet available
Pathways
NETPATH
REACTOME
REACT_6344
Tat-mediated HIV elongation arrest and recovery pathway
REACT_6143
Pausing and recovery of Tat-mediated HIV elongation pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6244
Pausing and recovery of HIV elongation pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6261
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
REACT_6259
HIV elongation arrest and recovery pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003168
HUGO
OMIM
CCDS CCDS11606
HPRD 16026
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca