Version 5.4
Homo sapiens Gene: SEMA3A
Summary
InnateDB Gene IDBG-24546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA3A
Gene Name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms coll-1; COLL1; HH16; Hsema-I; Hsema-III; SEMA1; SEMAD; SEMAIII; SEMAL; SemD
Species Homo sapiens
Ensembl Gene ENSG00000075213
Encoded Proteins
IDBP-24548
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
IDBP-380584
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
IDBP-380587
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
IDBP-380591
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
IDBP-380593
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21098092
SEMA3A is a ligand for PLXNA4, and the overexpression of SEMA3A exacerbate cytokine storm caused by TLR agonist and bacterial sepsis. The expression of SEMA3A can be induced by TLR engagement, and thus completes an autocrine loop.
InnateDB Annotation from Orthologs
Summary
PMID 21098092
[Mus musculus] Sema3a is a ligand for Plxna4, and the overexpression of Sema3a exacerbate cytokine storm caused by Tlr agonist and bacterial sepsis. The expression of Sema3a can be induced by Tlr engagement, and thus completes an autocrine loop.
Entrez Gene
Summary This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer\'s disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:83955777-84492724
Strand Reverse strand
Band q21.11
Transcripts
ENST00000265362 ENSP00000265362
ENST00000436949 ENSP00000415260
ENST00000420047 ENSP00000391900
ENST00000448879 ENSP00000402093
ENST00000424555 ENSP00000404800
ENST00000471474
ENST00000490883
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
GO:0038191 neuropilin binding
GO:0045499 chemorepellent activity
Biological Process
GO:0001764 neuron migration
GO:0002027 regulation of heart rate
GO:0006915 apoptotic process
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0008045 motor neuron axon guidance
GO:0010633 negative regulation of epithelial cell migration
GO:0021612 facial nerve structural organization
GO:0021637 trigeminal nerve structural organization
GO:0021675 nerve development
GO:0021772 olfactory bulb development
GO:0021785 branchiomotor neuron axon guidance
GO:0021828 gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0030517 negative regulation of axon extension
GO:0045087 innate immune response (InnateDB)
GO:0048485 sympathetic nervous system development
GO:0048813 dendrite morphogenesis
GO:0048841 regulation of axon extension involved in axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048846 axon extension involved in axon guidance
GO:0048880 sensory system development
GO:0050919 negative chemotaxis
GO:0060385 axonogenesis involved in innervation
GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching
GO:0061549 sympathetic ganglion development
GO:0071526 semaphorin-plexin signaling pathway
GO:0097490 sympathetic neuron projection extension
GO:0097491 sympathetic neuron projection guidance
GO:1901166 neural crest cell migration involved in autonomic nervous system development
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance
GO:1903045 neural crest cell migration involved in sympathetic nervous system development
GO:2000020 positive regulation of male gonad development
GO:2001224 positive regulation of neuron migration
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028883
View Gene Order
ENSBTAG00000018133
Not yet available
Pathways
NETPATH
REACTOME
REACT_19199
CRMPs in Sema3A signaling pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_19279
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.252451
RefSeq NM_006080 XM_005250110 XM_005250111 XM_006715838 XM_006715839
HUGO
OMIM
CCDS CCDS5599
HPRD 04908
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca