InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SULF1

Summary

InnateDB Gene

IDBG-644683.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULF1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004720

Encoded Proteins

IDBP-697341

sulfatase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137573:
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:35476252-35558292

Strand

Forward strand

Band

Transcripts

ENSBTAT00000037267

ENSBTAP00000037103

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004065	arylsulfatase activity
GO:0005509	calcium ion binding
GO:0008449	N-acetylglucosamine-6-sulfatase activity
GO:0008484	sulfuric ester hydrolase activity

Biological Process

GO:0001502	cartilage condensation
GO:0001822	kidney development
GO:0001937	negative regulation of endothelial cell proliferation
GO:0002063	chondrocyte development
GO:0003094	glomerular filtration
GO:0007155	cell adhesion
GO:0008152	metabolic process
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0014846	esophagus smooth muscle contraction
GO:0016525	negative regulation of angiogenesis
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030201	heparan sulfate proteoglycan metabolic process
GO:0030336	negative regulation of cell migration
GO:0030513	positive regulation of BMP signaling pathway
GO:0032836	glomerular basement membrane development
GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway
GO:0036022	limb joint morphogenesis
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048706	embryonic skeletal system development
GO:0051216	cartilage development
GO:0060348	bone development
GO:0060384	innervation
GO:0060686	negative regulation of prostatic bud formation

Cellular Component

GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0045121	membrane raft

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000137573

View Gene Order

ENSMUSG00000016918

View Gene Order

Cross-References

SwissProt

TrEMBL

E1BGL6

UniProt Splice Variant

Entrez Gene

UniGene

Bt.111893 Bt.112263

RefSeq

HUGO

HGNC:20391

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02038770 DAAA02038771 DAAA02038772

GenPept

RNA Seq Atlas